During the French colonial period the school was renamed Collège Chasseloup Laubat, after the French minister of colonies. In 1954 it became Jean Jacques Rousseau, and in 1970 the Vietnamese authorities turned it into the Le Quy Don Education Center. Finally, on August 29, 1977, the city administration officially established Le Quy Don High School, the name it keeps today.

The institution has always followed the French curriculum. In the early 20th century it admitted Vietnamese students only if they possessed French citizenship, while French pupils studied in a separate European section; both groups sat the same baccalaureate exams.

Among its many distinguished former students is Cambodia’s late King Norodom Sihanouk. Other alumni include engineer and patriot Cao Trieu Phat, revolutionary Nguyen An Ninh, composer Trinh Cong Son, and astrophysicist Trinh Xuan Thuan, illustrating the school’s impact on politics, culture and science across the region.

Today the school is recognised as a cultural heritage site and meets Level 2 national standards – the highest level in Vietnam’s school‑quality framework – confirming its continued prestige in modern education.