The aircraft departed L.F. Wade International Airport in Bermuda, heading for Boston Logan International Airport. Contact was lost at about 1:30 a.m. Eastern Time, according to flight‑tracking data.

The U.S. Federal Aviation Administration issued a search‑and‑rescue alert at 1:20 a.m. ET and said it is coordinating with the Rescue Coordination Center and the U.S. Coast Guard. The Coast Guard’s northeast division posted that air and surface teams are searching off the coast of Nantucket, Massachusetts.

Clarence Togeretz, director of flight operations at Latitude Air Ambulance, said the crew consists of two Canadian pilots and two Canadian medical staff. The patient and a relative travelling with them are not Canadian.

Canadian Transport Minister Steven MacKinnon said the government is closely monitoring the situation and working with U.S. authorities, adding his thoughts for everyone on board and their families.

Hugo Fontaine, spokesperson for the Transportation Safety Board of Canada, said the board is gathering information to assess what happened. The incident underscores how quickly cross‑border emergencies require coordinated search‑and‑rescue efforts and raises questions about safety standards for medical‑evacuation flights over international waters.